TNFRSF17 - TNF receptor superfamily member 17 Gene

Also Known as BCM; BCMA; CD269; TNFRSF13A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 608

About TNFRSF17

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,965,210-11,968,068 (from NCBI)

This gene has 3 transcripts (splice variants), 106 orthologues, 1 paralogue and is associated with 36 phenotypes. Biased expression in lymph node (RPKM 11.9), duodenum (RPKM 11.5) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

TNFRSF17 Products (1)

mRNA	Protein	Name
NM_001192.3	NP_001183.2	tumor necrosis factor receptor superfamily member 17

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF17 Protein Structure

BCMA-Tall_bind

0
100
184 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 17	B cell maturation antigen

TNFRSF17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFRSF17	Q02223	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
Intra	TNFRSF17	Q02223	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF17 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7132	BCMA/TNFRSF17 Protein, Human	Q02223 (A5-A54)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7654	BCMA/TNFRSF17 Protein, Human (HEK293, Fc)	Q02223 (M1-A54)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7655	BCMA/TNFRSF17 Protein, Human (P.pastoris, His)	Q02223 (M1-A54)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P70827	BCMA/TNFRSF17 Protein, Human (HEK293, mFc)	Q02223 (M1-A54)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72342	BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q02223 (M1-A54)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72847	BCMA/TNFRSF17 Protein, Human (HEK293, His)	Q02223 (M1-A54)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78070	BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, His-Avi)	Q02223 (M1-A54)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78071	BCMA/TNFRSF17 Trimer Protein, Human (Biotinylated, HEK293, His-Avi)	Q02223 (M1-A54)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78388	BCMA/TNFRSF17 Protein, Human (HEK293, His-Avi)	Q02223 (M1-A54)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78389	BCMA/TNFRSF17 Trimer Protein, Human (HEK293, His-Avi)	Q02223 (M1-A54)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700663	FITC-labeled BCMA/TNFRSF17 Protein, Human (HEK293, His-Avi)	Q02223 (M1-A54)	≥ 95%, as determined by reducing SDS-PAGE.

TNFRSF17 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81756	CD269/BCMA Antibody (YA1501)	ICC/IF, FC, IP, ELISA	Human
HY-P84468	CD269/BCMA Antibody (YA4165)	FC, ELISA	Human
HY-P84468A	CD269/BCMA Antibody (YA4165)(PBS only)	FC, ELISA	Human
HY-P84980	CD269/BCMA Antibody (YA4672)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Macroglobulinemia	Primary Macroglobulinemia Waldenstrom Macroglobulinemia
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Cardiomyopathy, Familial Hypertrophic, 12	Hypertrophic Cardiomyopathy 12 CMH12 Cardiomyopathy, Hypertrophic, 12 Cardiomyopathy Familial Hypertrophic 12 Cardiomyopathy, Familial Hypertrophic 12 Cardiomyopathy, Hypertrophic, Familial, Type 12
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Cardiomyopathy, Dilated, 2a	Dilated Cardiomyopathy 2a CMD2A Cardiomyopathy, Dilated, Autosomal Recessive Cardiomyopathy, Congestive, Autosomal Recessive Cardiomyopathy, Dilated 2a Cardiomyopathy, Dilated, Type 2a Autosomal Recessive Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1ff	Dilated Cardiomyopathy 1ff CMD1FF Cardiomyopathy, Dilated 1ff Cardiomyopathy, Dilated, Type 1ff
Smoldering Myeloma
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Granulomatous Amebic Encephalitis	Granulomatous Amoebic Encephalitis Acanthamoeba Encephalitis Acanthamoeba Granulomatous Encephalitis Granulomatous Amebic Encephalitis Due To Acanthamoeba
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Primary Amebic Meningoencephalitis	Pam Naegleria Fowleri Infection Meningoencephalitis Caused By Naegleria Fowleri Primary Amoebic Meningoencephalitis
Retinitis Pigmentosa 90	RP90 Retinitis Pigmentosa, Type 90
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Anemia, Congenital Dyserythropoietic, Type Ib	CDAN1B Congenital Dyserythropoietic Anemia Type Ib Cda, Type Ib Congenital Dyserythropoietic Anemia Type Type 1b Dyserythropoietic Anemia, Congenital, Type Ib Anemia, Congenital Dyserythropoietic, 1b Cda Ib Anemia, Dyserythropoietic, Congenital Anemia, Dyserythropoietic, Congenital, Type Ib
Monoclonal Gammopathy Of Uncertain Significance	Monoclonal Gammopathy Of Undetermined Significance Mgus Mgus - [Monoclonal Gammopathy Of Undetermined Significance] Monoclonal Gammopathy Nos Iga Gammopathy Monoclonal Gammoglobulinopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99909	Elranatamab		98.74%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9980	Belantamab	Inhibitor	99.90%	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-185002	BCMA CAR mRNA		/	Unkown
HY-RS14807	TNFRSF17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16981	Tnfrsf17 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23424	Tnfrsf17 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991155	Ramantamig	Inhibitor	95%	Unkown
HY-P9980A	Belantamab (FUT8-KO)		98.10%	Unkown
HY-P990686	Ispectamab		98.102%	Unkown
HY-P991686	Gamgertamig	Inhibitor	99.32%	Unkown
HY-P991014	Pamlectabart	Inhibitor	97.00%	Unkown
HY-P990939	Podentamig	Inhibitor	/	Unkown
HY-P992136	Torutamig	Inhibitor	/	Unkown
HY-P991003	Ingitamig	Inhibitor	/	Unkown
HY-P991878	TBL-CLN1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFRSF17	MGD	MGI:1343050
Canis familiaris	TNFRSF17	VGNC	VGNC:47659
Macaca mulatta	TNFRSF17	VGNC	VGNC:78586
Bos taurus	TNFRSF17	VGNC	VGNC:106989
Rattus norvegicus	TNFRSF17	RGD	RGD:1304703
Others	TNFRSF17	NCBI