TNFRSF17 - TNF receptor superfamily member 17 Gene

Also Known as BCM; BCMA; CD269; TNFRSF13A

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 608

About TNFRSF17

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,965,210-11,968,068 (from NCBI)

This gene has 3 transcripts (splice variants), 106 orthologues, 1 paralogue and is associated with 36 phenotypes. Biased expression in lymph node (RPKM 11.9), duodenum (RPKM 11.5) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

TNFRSF17 Products (1)

mRNA Protein Name
NM_001192.3 NP_001183.2 tumor necrosis factor receptor superfamily member 17

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF17 Protein Structure

BCMA-Tall_bind

BCMA-Tall_bind: BCMA, TALL-1 binding (8 - 46)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 17

  • B cell maturation antigen

TNFRSF17 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
TNFRSF17 Q02223 CMTM7 Homo sapiens Q96FZ5
Validated Y2H
32296183
Intra
TNFRSF17 Q02223 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF17 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P7132 BCMA/TNFRSF17 Protein, Human Q02223 (A5-A54) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7654 BCMA/TNFRSF17 Protein, Human (HEK293, Fc) Q02223 (M1-A54) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7655 BCMA/TNFRSF17 Protein, Human (P.pastoris, His) Q02223 (M1-A54) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P70827 BCMA/TNFRSF17 Protein, Human (HEK293, mFc) Q02223 (M1-A54) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72342 BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q02223 (M1-A54) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72847 BCMA/TNFRSF17 Protein, Human (HEK293, His) Q02223 (M1-A54) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78070 BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, His-Avi) Q02223 (M1-A54) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78071 BCMA/TNFRSF17 Trimer Protein, Human (Biotinylated, HEK293, His-Avi) Q02223 (M1-A54) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78388 BCMA/TNFRSF17 Protein, Human (HEK293, His-Avi) Q02223 (M1-A54) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78389 BCMA/TNFRSF17 Trimer Protein, Human (HEK293, His-Avi) Q02223 (M1-A54) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700663 FITC-labeled BCMA/TNFRSF17 Protein, Human (HEK293, His-Avi) Q02223 (M1-A54) ≥ 95%, as determined by reducing SDS-PAGE.

TNFRSF17 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81756 CD269/BCMA Antibody (YA1501) ICC/IF, FC, IP, ELISA Human
HY-P84468 CD269/BCMA Antibody (YA4165) FC, ELISA Human
HY-P84468A CD269/BCMA Antibody (YA4165)(PBS only) FC, ELISA Human
HY-P84980 CD269/BCMA Antibody (YA4672) FC, ELISA Human

関連疾患

Diseases Alias
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Macroglobulinemia

  • Primary Macroglobulinemia

  • Waldenstrom Macroglobulinemia
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Common Variable Immunodeficiency

  • Cvid

  • Common Variable Agammaglobulinemia

  • Common Variable Immune Deficiency

  • Acquired Hypogammaglobulinemia

  • Hypogamma-Globulinemia, Acquired

  • Idiopathic Immunoglobulin Deficiency

  • Primary Antibody Deficiency

  • Primary Hypogammaglobulinemia

  • Acquired Agammaglobulinemia

  • Sporadic Hypogammaglobulinemia

  • Common Variable Hypogamma-Globulinemia

  • Immunoglobulin Deficiency, Late-Onset

  • Common Variable Hypogammaglobulinemia

  • Immunodeficiency, Common Variable
Cardiomyopathy, Familial Hypertrophic, 12

  • Hypertrophic Cardiomyopathy 12

  • CMH12

  • Cardiomyopathy, Hypertrophic, 12

  • Cardiomyopathy Familial Hypertrophic 12

  • Cardiomyopathy, Familial Hypertrophic 12

  • Cardiomyopathy, Hypertrophic, Familial, Type 12
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Cardiomyopathy, Dilated, 2a

  • Dilated Cardiomyopathy 2a

  • CMD2A

  • Cardiomyopathy, Dilated, Autosomal Recessive

  • Cardiomyopathy, Congestive, Autosomal Recessive

  • Cardiomyopathy, Dilated 2a

  • Cardiomyopathy, Dilated, Type 2a

  • Autosomal Recessive Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1ff

  • Dilated Cardiomyopathy 1ff

  • CMD1FF

  • Cardiomyopathy, Dilated 1ff

  • Cardiomyopathy, Dilated, Type 1ff
Smoldering Myeloma
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Granulomatous Amebic Encephalitis

  • Granulomatous Amoebic Encephalitis

  • Acanthamoeba Encephalitis

  • Acanthamoeba Granulomatous Encephalitis

  • Granulomatous Amebic Encephalitis Due To Acanthamoeba
Follicular Lymphoma

  • Lymphoma, Follicular

  • Lymphoma Follicular

  • Brill-Symmers' Disease

  • Large Cell Follicular Non-Hodgkin Lymphoma

  • Diffuse Follicle Centre Lymphoma

  • Diffuse Follicular Lymphoma Nos

  • Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

  • Follicular Large Cell Cleaved Or Noncleaved Lymphoma

  • Large Cell Follicular Noncleaved Lymphoma

  • Follicular Lymphoma With Or Without Diffuse Areas

  • Histiocytic Follicular Lymphoma

  • Histiocytic Nodular Lymphoma

  • Histiocytic Nodular Malignant Lymphoma

  • Large Cell Follicular Lymphoma

  • Large Cell Noncleaved Follicular Lymphoma

  • Large Cell Noncleaved Follicular Malignant Lymphoma

  • Nodular Reticulum Cell Sarcoma

  • Noncleaved Follicular Lymphoma
Primary Amebic Meningoencephalitis

  • Pam

  • Naegleria Fowleri Infection

  • Meningoencephalitis Caused By Naegleria Fowleri

  • Primary Amoebic Meningoencephalitis
Retinitis Pigmentosa 90

  • RP90

  • Retinitis Pigmentosa, Type 90
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, Non-Hodgkin, Familial

  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma
Anemia, Congenital Dyserythropoietic, Type Ib

  • CDAN1B

  • Congenital Dyserythropoietic Anemia Type Ib

  • Cda, Type Ib

  • Congenital Dyserythropoietic Anemia Type Type 1b

  • Dyserythropoietic Anemia, Congenital, Type Ib

  • Anemia, Congenital Dyserythropoietic, 1b

  • Cda Ib

  • Anemia, Dyserythropoietic, Congenital

  • Anemia, Dyserythropoietic, Congenital, Type Ib
Monoclonal Gammopathy Of Uncertain Significance

  • Monoclonal Gammopathy Of Undetermined Significance

  • Mgus

  • Mgus - [Monoclonal Gammopathy Of Undetermined Significance]

  • Monoclonal Gammopathy Nos

  • Iga Gammopathy

  • Monoclonal Gammoglobulinopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

阻害性抗体 (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-P99909 Elranatamab 98.74% Unkown

Clinical Phase

阻害性抗体 (1)
製品番号 製品名 製品効果
純度 Phase
HY-P9980 Belantamab Inhibitor 99.90% Phase 3

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-185002 BCMA CAR mRNA / Unkown
HY-RS14807 TNFRSF17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16981 Tnfrsf17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23424 Tnfrsf17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (9)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P991155 Ramantamig Inhibitor 95% Unkown
HY-P9980A Belantamab (FUT8-KO) 98.10% Unkown
HY-P990686 Ispectamab 98.102% Unkown
HY-P991686 Gamgertamig Inhibitor 99.32% Unkown
HY-P991014 Pamlectabart Inhibitor 97.00% Unkown
HY-P990939 Podentamig Inhibitor / Unkown
HY-P992136 Torutamig Inhibitor / Unkown
HY-P991003 Ingitamig Inhibitor / Unkown
HY-P991878 TBL-CLN1 / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus TNFRSF17 MGD MGI:1343050
Canis familiaris TNFRSF17 VGNC VGNC:47659
Macaca mulatta TNFRSF17 VGNC VGNC:78586
Bos taurus TNFRSF17 VGNC VGNC:106989
Rattus norvegicus TNFRSF17 RGD RGD:1304703
Others TNFRSF17 NCBI